Espacio profesional sobre esquizofrenia, depresión y trastorno bipolar

Adiponectin predicts poor response to antidepressant drugs in major depressive disorder.

Benedetti F
Branchi I
Poletti S
Lorenzi C
Bigai G
Colombo C
Zanardi R
Produced by adipocytes, adiponectin crosses the blood-brain barrier to bind with specific receptors in the hypothalamus, brainstem, hippocampus, and cortex. In patients with major depressive disorder (MDD), circulating levels of adiponectin inversely related with antidepressant response to ketamine, and predicted a better response to multi-target drug combinations than to escitalopram. We investigated the effect of adiponectin on response to antidepressants in a naturalistic setting.
National Center for Biotechnology Information (NCBI)[Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; [1988] - [cited 2021 Jun 1]. Available from: